Ana Pamplona,Gonçalo J. L. Bernardes,Maria M. Mota,Carlos C. Romão
申请号：
US14711113
公开号：
US09611286B2
申请日:
2015.05.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides novel ruthenium compounds of Formula (I):or salts, isomers, hydrates, or solvates thereof, or combinations thereof； wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute resipiratory distress syndrome, which optionally may be associated with a malaria infection.
