Claim 1: A compound of formula (1) for use in the treatment of a cancer, wherein said cancer is treated by modulating an immune response comprising a reactivation of the immune system in the tumor； wherein said compound is optionally used in combination with one or more chemotherapy and / or radiotherapy and / or targeted therapy agents； where in compounds of formula (1) (R¹) ₙ represents one, two or three optional substituents on the phenyl ring, where said substituents are independently selected from C₁₋₃-alkyl,C₁₋₃ alkoxy,-S-lease c8321c83183323；Halogen, calcium fluoride c8332123；Hydrogen fluoride c83218c83183323；ciano hidroxi nitro -CO-O-alquilo-C-NRN⁷RN⁸ where RN⁷ and RN⁸ independently represent hydrogen or C₁₋₄ alkyl,O No. rn-831181 and rn831222 form a 4-6 carbon circle together with the attached nitrogen； R3 represents hydrogen, methyl or trifluoroamide； r8308； r8308； 7491 and r8308； 74959 independently represents hydrogen, methyl or r8308； 7491 and r8308； 74955 together with the attached carbon atom represents a cyclopropane-1, 1-diilo group； R8309；； 749191 and r8309；； 74955 stands for hydrogen, methyl or r8309；； 749191 and r8309；； 74959, together with the carbon atom connected to it, stands for one cyclopropene-1, 1-bis； AR1 stands for phenyl, or 5 or 6 member heteromorphism； 5 or 6 member phenyl or heteromorphism, stands alone in monkey -,di- or tri-substituted where the substituents are independently selected from C₁₋₆-alkyl；C₁₋₄ alkoxy；Calcium fluoride c8321c83183323；a. Calcium fluoride c83216c833183323 can be replaced by hydrogen Xi； calcium fluoride c83318323；Keywords halogen； cyanogen； cyclopentanediol c833238331-832626；wherein said C₃₋₆ cycloalkyl is unsubstituted or mono-substituted with amino； C₄₋₆ cycloalkyl containing a ring oxygen atom, wherein said C₄₋₆ cycloalkyl containing a ring oxygen atom is unsubstituted or mono-substituted with hydroxy； C₃₋₆-oxy cycloalkyl； hydroxy； -X¹-CO-RO¹,where X¹ represents a direct bond, alkylene C₁₋₃,1. Asphalt-o
