Pharmaceutical compositions containing these compounds； and processes for its preparation. Claim 1: A compound of formula (1) where: R¹ represents hydrogen, C₁₋₄ alkyl,C₁₋₄ alkoxy,Calcium fluoride c8321c83318324；C₁₋₄ alkylsulfonyl,Halogen or cyanogen； R2 for hydrogen or halogen； 1m3,R83088 and r83099a represent carboxi acquilo c83221；carboxy-cyclopropyl or carboxy-alkoxy C₁₋₃ and the other two represent, independently of each other,hydrogen, C₁₋₄ alkoxy or halogen； R⁶ represents hydrogen, C₁₋₄ alkoxy or halogen； R⁷ represents hydrogen, C₁₋₄ alkyl,C₁₋₄ alkoxy,C₃₋₆-methoxy cycloalkyl, C₃₋₆ cycloalkyloxy,methoxy-ethoxy, di- [C₁₋₂ alkyl] -amino, fluoroalkyl Cilo,Hydrogen fluoride c83218c83183242；e. Halogen or acrylonitrile c83321s 833124；or R⁶ and R⁷ together represent methylenedioxy or ethylenedioxy； R⁸ represents: C₂₋₅ alkyl；C₁₋₅-alkyl that is mono- or di-substituted where the substituents are independently selected from the group consisting of hydroxy, C₁₋₄-alkoxy,oxo -NR Roptionally substituted C₃₋₆ cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aryloxy, optionally substituted heteroaryloxy, or optionally substituted aryl-alkoxy； C₃₋₅ alkenyl；C₂₋₃ alkenyl that is mono-substituted with optionally substituted aryl or optionally substituted heteroaryl； C₃₋₅ alkynyl；C₃₋₆ cycloalkyl which is unsubstituted, mono-,Say...tri- or tetra-substituted with methyl； mono-substituted with oxo； mono-substituted with optionally substituted aryl； or mono-substituted with optionally substituted heteroaryl； or heterocyclyl that is optionally mono-substituted with oxo； R⁹ represents C₁₋₄ alkyl；R183044 stands for optional diphenyl； n stands for 1 or 2； m stands for 1 or 2； Z stands for - NH -,-O - or link, or salt this compound.Composiciones farmacéuticas que contienen estos compuestos； y a procesos para su preparación. Reivindicación 1: Un compuesto de la fórmula (1) donde: R¹ representa hidrógeno, a
