1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS农业专利-农业学术服务平台

发明人:: AISSAOUI, HAMED,艾赛奥汉姆德,艾賽奧漢姆德,BOSS, CHRISTOPH,博斯克里斯多夫,博斯克里斯多夫,FECHER, ANJA,费区安杰,費區安傑,POTHIER, JULIEN,波提尔朱利安,波提爾朱利安,RICHARD-BILDSTEIN, SYLVIA,理查比得史登席微亚,理查比得史登席微亞,RISCH, PHILIPPE,瑞许菲利浦,瑞許菲

摘要：: The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I),wherein X, Y, Z, n, R1, R2, R3, R4, R5, R6, R7 and R10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.本發明係關於式(I)之1-苯基取代之雜環衍生物,其中X、Y、Z、n、R1、R2、R3、R4、R5、R6、R7及R10係如發明說明所述;及其作為前列腺素受體調節劑,最特別作為前列腺素D2受體調節劑在治療各種前列腺素介導之疾病及病症中之用途;並關於含有此等化合物之醫藥組合物及其製備方法。