CID-NUNEZ, JOSÉ,TRABANCO-SUAREZ, ANDRÉS,OEHLRICH, DANIEL,TRESADERN, GARY,MACDONALD, GREGOR,VEGA RAMIRO, JUAN
申请号：
ES11781523
公开号：
ES2552455T3
申请日:
2011.11.08
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I) ** Formula ** or a stereochemically isomeric form thereof, wherein R 1 is selected from the group consisting of C 1-6 alkyl； (C3-8 cycloalkyl) C1-3 alkyl； (C1-3 alkyloxy) C1-3 alkyl； and C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； R2 is selected from the group consisting of Cl, CF3, -CN and cyclopropyl； R3 is selected from the group consisting of hydrogen, methyl and CF3； R4 is selected from the group consisting of hydrogen and methyl； or R3 and R4 together with the carbon to which they are attached form a cyclopropyl ring； L is selected from the group consisting of (La), (Lb), (Ld), (Lc), (Le), (Lf), (Lh) and (Lg): ** Formula ** in which ma , mb, and mc are each independently selected from the group consisting of 0 and 1； me and mg are each independently selected from the group consisting of 1 and 2； na, nb, nc, nd, ne, nf, ng and nh are each independently selected from the group consisting of 0, 1 and 2； R5a, R5b, R5c, R5d, R5e, R5f, R5g and R5h are each independently selected from the group consisting of halo； C1-3 alkyl； C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； C1-3 alkyloxy； and C1-3 alkyloxy substituted with 1, 2 or 3 fluoro substituents； R6a is selected from the group consisting of hydrogen； halo； C1-3 alkyl； C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； C1-3 alkyloxy； and C1-3 alkyloxy substituted with 1, 2 or 3 fluoro substituents； R6c is selected from the group consisting of hydrogen； halo； C1-3 alkyl； C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； C1-3 alkyloxy； C1-3 alkyloxy substituted with 1, 2 or 3 fluoro substituents； and cyclopropyl； R7a, R8a, R7b and R8b are each independently selected from the group consisting of hydrogen, fluoro and methyl； or R7a and R8a, and R7b and R8b together with the carbon to which they are attached form a cyclopropyl or a carbonyl group； in which each halo is selected from the group consisting of fluoro, chloro, bromo and iodo； with the pr
