CID-NUNEZ, JOSÉ,TRABANCO-SUAREZ, ANDRÉS,VEGA RAMIRO, JUAN,OEHLRICH, DANIEL,TRESADERN, GARY,MACDONALD, GREGOR
申请号：
ES11781524
公开号：
ES2536433T3
申请日:
2011.11.08
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I) ** Formula ** or a stereoisomerically isomeric form thereof, wherein R 1 is selected from the group consisting of C 1-6 alkyl, (C 3-8 cycloalkyl) C 1-3 alkyl, (alkyloxy C1-3) C1-3 alkyl and C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； R2 is selected from the group consisting of Cl, CF3, -CN and cyclopropyl； R3 is selected from the group consisting of hydrogen, methyl and CF3； R4 is selected from the group consisting of hydrogen and methyl； or R3 and R4 together with the carbon to which they are attached form a cyclopropyl ring or a carbonyl group； L is selected from the group consisting of (Lc), (La), (Lb), (Ld), (Le), (Lf) and (Lg): in which R5a, R5b, R5c and R5d are selected each one independently among the group consisting of phenyl； phenyl substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyloxy and halo； pyridinyl； pyridinyl substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyl, C1-3 alkyloxy and halo； pyrimidinyl and pyrimidinyl substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyl, C1-3 alkyloxy and halo； R5e and R5f are each independently selected from the group consisting of phenyl and phenyl substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyloxy and halo； R5g is selected from the group consisting of C1-3 alkyl, phenyl and phenyl optionally substituted with 1 or 2 substituents each independently selected from the group consisting of C1-3 alkyloxy and halo； R6a, R6b, R6c, R6e, R6f and R6g are each independently selected from the group consisting of hydrogen； fluoro； C1-3 alkyl； C1-3 alkyl substituted with 1, 2 or 3 fluoro substituents； C1-3 alkyloxy； C1-3 alkyloxy substituted with 1, 2 or 3 fluoro substituents； and C3-6 cycloalkyl； R7a, R8a, R7b, R8b, R7c, R8c, R7d, R8d, R7e, R8e, R7f and R8f are each independently s
