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Fused bicyclic compound
专利权人:
Mitsubishi Tanabe Pharma Corporation
发明人:
Kawaguchi, Takayuki,Iijima, Toru,Takahashi, Yoichi,Awai, Nobumasa,Akatsuka, Hidenori
申请号:
AU2008283265
公开号:
AU2008283265B2
申请日:
2008.07.31
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Disclosed is a novel fused bicyclic compound [I] shown below, which has affinityfor a mineralcorticoid receptor (MR) and is useful as an anti-hypertensive agentor the like. Specifically disclosed is a compound represented by the formula[I] or a pharmacologically acceptable salt thereof. [I] whereinthe ring A represents a benzene ring which is fused with the adjacent heterocyclic6-membered ring and has a substituent R, and which may have a substituentother than R; R represents an alkylsulfonylamino groupor the like; R and R (a) independently represent a hydrogen,an alkyl or a substituted or unsubstituted aryl, (b) together form an oxo, or (c)together with the adjacent carbon atom, form a cycloalkyl; X represents =N-,=C(R)- or -CH(R)-; R represents (a) a hydrogen,(b) a cyano, (c) a halogen, (d) an alkyl, (e) an alkenyl, (f) a cycloalkyl, (g) analkanoyl, (h) a carbamoyl or (i) a cycloalkenyl; Ar represents a substitutedor unsubstituted aromatic cyclic group; and a dotted line means the presenceor absence of a double bond.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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