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Triazole derivative
专利权人:
大正製薬株式会社
发明人:
小野 直哉,高山 哲男,塩澤 史康,片貝 博典,薮内 哲也,太田 知己,八木 慎,佐藤 正和
申请号:
JP2007556950
公开号:
JP5035752B2
申请日:
2007.02.05
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P 1 ), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula -SO-, a group represented by Formula -SO 2 -, or the like, R 1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, R 1A represents a hydrogen atom or the like, R 2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, R 3 represents an aryl group, R 4 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and R 5 represents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).
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