Disclosed herein relates to immunotherapeutic compositions comprising immunotherapeutic peptides comprising neoepitopes, polynucleotides encoding the immunotherapeutic peptides, antigen presenting cells comprising the immunotherapeutic peptides or polynucleotides, or T cell receptors specific for the neoepitopes. Also disclosed herein is use of the immunotherapeutic compositions.本發明係關於免疫治療組合物，該組合物包含：包含新抗原決定基之免疫治療肽；編碼該等免疫治療肽之聚核苷酸；包含該等免疫治療肽或聚核苷酸之抗原呈現細胞；或對該等新抗原決定基具有特異性的T細胞受體。本發明亦揭示該等免疫治療組合物之用途。
