Provided herein are tumor-antigen VCX/Y specific peptides and engineered VCX/Y specific T cell receptors. Also provided herein are methods of generating VCX/Y-specific immune cells and their use for the treatment of cancer. In addition, the VCX/Y-specific peptides may be used as a vaccine.本發明提供腫瘤抗原VCX/Y特異性肽及經工程改造之VCX/Y特異性T細胞受體。本發明亦提供產生VCX/Y特異性免疫細胞之方法及其用於治療癌症之用途。另外,VCX/Y特異性肽可用作疫苗。