The disclosure herein relates to immunotherapeutic compositions comprising immunotherapeutic peptides comprising neoepitopes. Also disclosed herrein are polynucleotides encoding the immunotherapeutic peptides. Also disclosed herein are methods of synthesis of immunotherapeutic peptides comprising neoepitopes and use of the immunotherapeutic compositions including methods of treatment.本發明係關於免疫治療組合物,其包含含有新抗原決定基之免疫治療肽。本文亦揭示編碼該等免疫治療肽之聚核苷酸。本文亦揭示合成包含新抗原決定基之免疫治療肽的方法及一種免疫治療組合物的用途,包括治療方法。