Disclosed herein relates to immunotherapeutic compositions comprising immunotherapeutic peptides comprising neoepitopes, polynucleotides encoding the immunotherapeutic peptides, antigen presenting cells comprising the immunotherapeutic peptides or polynucleotides, or T cell receptors specific for the neoepitopes. Also disclosed herein is use of the immunotherapeutic compositions.本文所揭示的係關於免疫治療組合物，其包含下列：含有新抗原決定基之免疫治療肽、編碼該等免疫治療肽之聚核苷酸、含有該等免疫治療肽或該等聚核苷酸之抗原呈現細胞、或對該等新抗原決定基具有特異性的T細胞受體。本文亦揭示該等免疫治療組合物之用途。
