Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the TTLL4 gene that elicit CTLs are provided. Antigen-presenting cells and isolated CTLs that target such peptides, as well as methods for inducing the antigen-presenting cell, or CTL are also provided. The present invention further provides pharmaceutical compositions containing peptides derived from TTLL4 or polynucleotides encoding the polypeptides as active ingredients. Furthermore, the present invention provides methods for the treatment and/or prophylaxis of (i.e., preventing) cancers (tumors), and/or the prevention of a postoperative recurrence thereof, as well as methods for inducing CTLs, methods for inducing anti-tumor immunity, using the peptides derived from TTLL4, polynucleotides encoding the peptides, or antigen-presenting cells presenting the peptides, or the pharmaceutical compositions of the present invention.於此敘述抗癌之胜肽疫苗。特別是,提供引起細胞毒殺性T淋巴球之來自TTLL4基因之抗原決定位胜肽。也提供以此類胜肽為目標之抗原呈現細胞與經分離之細胞毒殺性T淋巴球,及誘導原呈現細胞或細胞毒殺性T淋巴球的方法。本發明更提供包含來自TTLL4之胜肽或編碼出此多胜肽之多核苷酸為活性成分之藥學組合物。此外,藉由使用本發明來自TTLL4之胜肽、編碼出此胜肽之多核苷酸或呈現此胜肽的抗原呈現細胞或藥學組合物,本發明提供癌症(腫瘤)之治療及/或預防(即,避免)及/或其手術後復發的避免的方法,及誘導細胞毒殺性T淋巴球的方法,或誘導抗腫瘤免疫力的方法。
