Aduro Biotech, Inc.;The Regents of the University of California
发明人:
Dubensky, Thomas W.,Kanne, David B.,Leong, Meredith Lai Ling,Glickman, Laura Hix,Vance, Russell E.,Lemmens, Edward Emile
申请号：
HRP20191972
公开号：
HRP20191972T1
申请日:
2019.10.30
申请国别(地区):
HR
年份:
2020
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2′,5′,2′,5′ and 2′,5′,3′,5′ CDNs, and preferably Rp,Rp stereoisomers thereof.
