Thomas W. Dubensky, Jr.,David B. Kanne,Meredith Lai Ling Leong,Edward Emile Lemmens,Laura Hix Glickman
申请号：
US14106687
公开号：
US09695212B2
申请日:
2013.12.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers.
