DUBENSKY, THOMAS W., JR.,KANNE, DAVID B.,LEONG, MEREDITH LAI LING,LEMMENS, EDWARD EMILE,GLICKMAN, LAURA HIX
申请号：
CA2886456
公开号：
CA2886456A1
申请日:
2013.12.13
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers.
