COMPOSITIONS COMPRISING CYCLIC PURINE DINUCLEOTIDES HAVING DEFINED STEREOCHEMISTRIES AND METHODS FOR THEIR PREPARATION AND USE

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专利权人:

INC.;ADURO BIOTECH

发明人:

DUBENSKY, JR.,THOMAS, W.,KANNE, DAVID, B.,LEONG, MEREDITH, LAI LING,LEMMENS, EDWARD, EMILE,GLICKMAN, LAURA, HIX

申请号：

SG11201502796R

公开号：

SG11201502796RA

申请日:

2013.12.13

申请国别(地区):

SG

年份:

2015

代理人:

摘要：

It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinucleotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers.

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