DUBENSKY, Jr., Thomas, W. T W,小杜本斯基,KANNE, David, B. D B,肯奈,LEONG, Meredith, Lai Ling M L L,萊門斯,LEMMENS, Edward, Emile E E,格利克曼,GLICKMAN, Laura, Hix L H
申请号：
HK16100666.5
公开号：
HK1212707A
申请日:
2016.01.21
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers.
