DUBENSKY JR THOMAS W,KANNE DAVID B,LEONG MEREDITH LAI LING,LEMMENS EDWARD EMILE,GLICKMAN LAURA HIX
申请号：
IN605/MUMNP/2015
公开号：
IN2015MN00605A
申请日:
2015.03.19
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
It is an object of the present invention to provide novel and highly active cyclic di nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING dependent TBK1 activation wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp Rp or Rp Sp stereoisomers and particularly substantially pure Rp Rp or RpSp CDN thiophosphate diastereomers.
