КРОУ Брайан А. (AT),ЛИВИ Иан (AT),О'РУРК Мария (AT),ШВЕНДИНГЕР Михель (AT),ОРУРК Мария (AT)
申请号：
RU2012153972/10
公开号：
RU2012153972A
申请日:
2011.05.13
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. Chimeric polypeptide containing the first polypeptide fragment of the outer surface protein A (OspA) of serotype 3 Borrelia garinii and the second polypeptide fragment of the OspA protein of serotype 5 Borrella garinii, with the ability to induce an immune response against the OspA protein of serotype 3 and the OspA protein of serotype 5.2. The polypeptide according to claim 1, characterized in that it contains an N-terminal polypeptide fragment of the OspA serotype 5 protein and a C-terminal polypeptide fragment of the OspA protein of serotype 3.3. The polypeptide according to claim 1, characterized in that it contains an N-terminal polypeptide fragment of the OspA serotype 3 protein and a C-terminal polypeptide fragment of the OspA protein of serotype 5.4. The polypeptide according to claim 1, characterized in that it further comprises an N-terminal polypeptide fragment of the outer surface protein B (OspB) of Borrelia, wherein the OspB polypeptide fragment contains an OspB leader sequence. The polypeptide according to claim 1, containing an amino acid sequence having at least 200 amino acid residues, with at least or approximately 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99 percent sequence identity with the amino acid sequence shown in SEQ ID NO: 173.6. The polypeptide according to claims 1, 2 or 4, characterized in that it contains the amino acid sequence shown in SEQ ID NO: 173.7. The polypeptide according to claims 1, 2 or 4, characterized in that it consists of the amino acid sequence shown in SEQ ID NO: 173.8. A composition comprising a polypeptide according to any one of claims 1 to 7 and a pharmaceutically acceptable carrier. The composition of claim 8, characterized in that it further comprises an additional polypeptide of an external surface protein A (OspA) Borrelia. 10. The composition according to claim 9, characterized in1. Химерный полипептид, содержащий первый полипептидныйфрагмент внешнего поверхностно
