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FGF-R-FC fusion protein and its use
专利权人:
ЛТД. (CN);ЯНЬТАЙ ЖУНЧАН БАЙОТЕКНОЛОДЖИЗ КО.
发明人:
ФАН Цзяньминь (CN),ЛИ Дун (CN)
申请号:
RU2013140184/10
公开号:
RU2013140184A
申请日:
2012.05.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An isolated soluble fibroblast growth factor receptor (FGFR) fusion protein, a fusion protein comprising: a region of an intermediate functional sequence region derived from an Ig-like FGFR domain (IFS), 2nd Ig-like domain FGFR (D2) 3rd Ig-like domain of FGFR (D3), and immunoglobulin Fc region. 2. The fusion protein of claim 1 in vivo and / or in vitro fibroblast growth factor (FGF) is preferably associated with FGF2.3. A fusion protein according to claim 1, characterized in that the fragment obtained from IFS contains or does not contain an acidic box (AB), the IFS fragment preferably does not contain an acidic cell. The fusion protein of claim 1, wherein said fragment derived from IFS contains the amino acid sequence shown in SEQ ID NO: 1, No. 134-162, No. 145-162, or No. 151-162.5. The fusion protein according to claim 1, also contains the 1st Ig-like domain of FGFR (D1) or part thereof. A fusion protein according to claim 5, characterized in that the 1st Ig-like domain of FGFR or part thereof has: the amino acid sequence shown in SEQ ID NO: 1, No. 40-118, or an amino acid sequence that has at least 70% sequence identity, preferably at least 80%, 90%, 93%, 95%, 97%, 98% or 99% with any amino acid sequence from SEQ ID NO: 1 No. 40-118; or the amino acid sequence shown in SEQ ID NO: 1 No. 77-118, or the amino acid sequence that has at least 70% sequence identity, preferably at least 80%, 90%, 93%, 95%, 97% , 98% or 99% with any amino acid sequence from SEQ ID NO: 1 No. 77-118.7. The fusion protein of claim 1, wherein said domain comprises: the amino acid sequence shown in SEQ ID NO: 1 No. 163-247, or an amine1. Слитый белок рецептора выделенного растворимого фактора роста фибробластов (FGFR), слитый белок, содержащий: участок области промежуточной функциональной последовательности, полученный из Ig-подобного домена FGFR (IFS), 2-й Ig-подобный домен FGFR (D2) 3-й Ig-подобный домен FGFR (D3), и область Fc иммуноглобулина.2. Слитый белок по п. 1 в естественных усло
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