БАХМАНН Мартин (CH),ДЖЕННИНГС Гэри (CH),РЁН Тилль (CH)
申请号：
RU2010129538/15
公开号：
RU2010129538A
申请日:
2008.12.22
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A composition that includes:! (a) a virus-like particle (VLP) with at least one first attachment site； and! (b) at least one antigen with at least one second attachment site,! where at least one of the specified antigen is an NGF antigen； ! and where (a) and (b) are linked through said at least one first and said at least one second attachment site. ! 2. The composition according to claim 1, where the specified at least one antigen is an NGF protein, NGF fragment or NGF mutein. ! 3. The composition according to claim 1, where the specified at least one antigen is an NGF protein, where the specified NGF protein consists of an amino acid sequence, where the specified amino acid sequence has at least 90% sequence identity with the amino acid sequence SEQ ID NO: 22, and where preferably said NGF protein consists of the amino acid sequence of SEQ ID NO: 22. ! 4. The composition according to claim 1, where the specified at least one antigen is an NGF fragment, where preferably the specified NGF fragment consists of SEQ ID NO: 44. ! 5. The composition according to claim 1, wherein said at least one antigen is an NGF mutein, where preferably said NGF mutein has reduced biological activity, and where most preferably said NGF mutein does not have biological activity. ! 6. The composition according to claim 1, where the specified at least one antigen is an NGF mutein, and where the specified NGF mutein consists of an amino acid sequence1. Композиция, которая включает: ! (a) вирусоподобную частицу (VLP), по крайней мере, с одним первым сайтом присоединения； и ! (b) по крайней мере, один антиген, по крайней мере, с одним вторым сайтом присоединения, ! где, по крайней мере один указанный антиген представляет собой NGF антиген； ! и где (а) и (b) являются связанными посредством указанного, по крайней мере, одного первого и указанного, по крайней мере, одного второго сайта присоединения. ! 2. Композиция в соответствии с п.1, где указанный, по крайней мере, один антиген предс
