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Pyrazolopyridine derivatives as TTX-S blockers
专利权人:
RaQualia Pharma Inc
发明人:
KAWAMURA, Kiyoshi,YAMAGISHI, Tatsuya,ARANO, Yoshimasa,MORITA, Mikio
申请号:
ES13851886
公开号:
ES2661585T3
申请日:
2013.10.31
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of the following formula (I): ** Formula ** in which: A is aryl; -B-C- is -NH- (C>; = O) - or - (C>; = O) -NH-; R1 is independently selected from the group consisting of; (1) hydrogen, (2) -On-C 1-6 alkyl where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R 11, (3) -C 3-7 cycloalkyl where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R11, (4) -On-aryl where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11, (5) -C1-6 alkyl, where the alkyl is without replace or substituted with one or more substituents independently selected from R11, (6) -S-aryl where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11; (7) -NH-C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more substituents independently selected from R11 and (8) -NH-aryl, where the aryl is unsubstituted or substituted with one or more substituents independently selected from R11; in which n is independently 0 or 1, when n is 0, a chemical bond is present in the place of -On-; R2 is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl, (4) -On-C1-6 alkyl, where the alkyl is unsubstituted or substituted with one or more selected substituents independently of R7, (5) -C3-6 cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents independently selected from R7, (6) -C2-4 -n-alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents independently selected from R7, (7) -On-phenyl or -On-naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents independently selected from R7, (8) -On -heterocyclyl, where the heterocyclyl is unsubstituted or substituted with one or more substituents independently selected from R7, (9) -
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