FIELD: chemistry.SUBSTANCE: invention relates to the amide derivatives of formula,where A is selected from the group consisting of phenyl, benzoimidazolyl, dihydroisoquinoline, indole, indazole, pyrazolyl, pyrazinyl, pyridazinyl, pyridyl, chinoline, sochinila and thiazolyl； B is selected from the group consisting of chemical bond, -C1-6alkylene-, -O-C1-6alkylene- and -NR7-； W is hydrogen or C1-6 alkyl； Z represents a nitrogen atom or CH； R1 represents a fluorinated substituent, independently selected from the group consisting of -CF3, -CHF2, -OCF3, -OCHF2, -OCH2CHF2, -OCH2CF3, -OCF2CHF2, -OCF2CF3, -OCH2CH2CF3, -OCH(CH3)CF3, -OCH2C(CH3)F2, -OCH2CF2CHF2, -OCH2CF2CF3, -OCH2CH2OCH2CF3, -NHCH2CF3, -SCF3, -SCH2CF3, -CH2CF3, -C (CH3)2CF3, -CH2CH2CF3, -CH2OCH2CF3, -OCH2CH2OCF3, 4,4-difluoropiperidino and (4-fluorobenzyl) oxy； R2 is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl, (4) -On-C1-6 alkyl, where specified alkyl is unsubstituted or substituted by one or more of the substituents independently selected from R7, (7) -On-phenyl or -On-naphthyl, where specified phenyl or naphthyl is unsubstituted or substituted by one or more of the substituents independently selected from R7, and (10) -NR8R9； where n represents 0 or 1； if n=0, a chemical bond is present instead of-On-； p represents 1, 2, 3, or 4； if p is two or more than two, R2 may be the same or different； R3 and R4 independently represent hydrogen or C1-6 alkyl； R5 is independently selected from the group consisting of: (1) hydrogen, (2) halogen, and (3) -On-C1-6 alkyl, where specified alkyl is unsubstituted or substituted by one or more of the substituents independently selected from R7, where n represents 0 or 1； if n=0, a chemical bond is present instead of -On-； q represents 1, 2, or 3； if q is equal to two or more than two, R5 may be the same or different； R6 independently represents hydrogen, C1-6 alkyl, C2-6alkenyl, C3-7 cycloalkyl, phenyl, or heterocyclic group, w
