PRODROGUE POUR LIBERATION DE CISPLATINE ET D'UN INHIBITEUR DE CYCLOOXYGENASE

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专利权人:

UNIVERSITY OF GEORGIA RESEARCH FOUNDATION; INC.

发明人:

DHAR, SHANTA,PATHAK, RAKESH

申请号：

CA2931638

公开号：

CA2931638A1

申请日:

2014.12.12

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Pt(IV) prodrugs include one or more conjugated cyclooxygenase inhibitor. Reduction of Pt(IV) to Pt(II) can result cisplatin and a cyclooxygenase inhibitor. For proof of concept, a Pt(IV) prodrug that can produce cisplatin and aspirin, Platin-A, was synthesized. Platin-A exhibited excellent anticancer and anti-inflammatory properties, which were better than the combination of free formulation of cisplatin and aspirin.

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中国工程科技知识中心

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http://www.ckcest.cn/home/