ЛАКХЕРСТ Кристофер А. (GB),ХОГХАН Алан Ф. (GB),БРЕЧЧА Перла (GB),СТОТТ Эндрю Дж. (GB),БУРЛИ Роланд В. (GB),ХЬЮС Саманта Дж. (GB),МУНОС-САНХУАН Игнасио (US),ДОМИНГЕЗ Селия (US),МАНГЕТТЕ Джон И. (US)
申请号：
RU2013136778/04
公开号：
RU2013136778A
申请日:
2012.01.23
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R and R are independently selected from optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl； R is selected from —COOH, —C (O) NH (OH) and - N (OH) C (O) R； R is selected from hydrogen and lower alkyl, optionally substituted halo； and R is selected from hydrogen and lower alkyl； where, if both R and R are phenyl and R is hydrogen, then R is —N (OH) C (O) H or —C (O) NH (OH). 2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I is selected from compounds of Formula II3. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I is selected from compounds of Formula III4. A compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen or methyl. A compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R 1 is —CF. 6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I is selected from compounds of Formula IV7. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I is selected from compounds of Formula V8. A compound according to any one of claims 1 to 7, or a pharmaceutically acceptable salt thereof, wherein R is selected from —C (O) NH (OH) and —N (OH) C (O) R. 9. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein R is —C (O) NH (OH). 10. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein R is —N (OH) C (O) R, wherein R is hydrogen. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein R is —N (OH) C (O) R, wherein R is methyl. The compound according to any one of claims 1 to 7 or its1. Сое
