1. The compound of formula (I) or formula (II) or its ionic pairs, salts, hydrates, solvates or metabolites, where R is hydrogen, (C-C) alkyl, substituted (C-C) alkyl or (C-C) alkyl substituted with one or more fluorine atoms； R- alkyl, substituted alkyl, acyl, substituted acyl, halogen, heteroalkyl, substituted heteroalkyl, —NO, —N, —OH, —S (O) R, —OR, —NRR, -CONRR, -COR or -OCR； R- hydrogen, (C — C) alkyl, (C — C) substituted alkyl, (C — C) alkyl substituted with one or more fluorine atoms, arylalkyl or substituted arylalkyl； R is hydrogen, (C — C) alkyl, (CC) substituted alkyl, (C — C) alkyl substituted with one or not how many fluorine, arylalkyl or substituted arylalkyl atoms； R and R are independently hydrogen, (C — C) alkyl, substituted (C — C) alkyl, (C — C) alkyl substituted by one or more fluorine atoms, heteroalkyl, substituted heteroalkyl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl or R and R together with the nitrogen atom to which they are attached form a cycloheteroalkyl or substituted cycloheteroalkyl ring； R is hydrogen, (C-C) alkyl or (C-C) alkyl substituted with one or more fluorine atoms ； R-R is independently hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl； k is 0.1 or 2 and n is 0, 1, 2 or 3.2. The compound of claim 1 of formula (III) or (IV) 3. A compound according to claim 2, wherein R is hydrogen, (C — C) alkyl or (C — C) alkyl substituted with one or more fluorine atoms. A compound according to claim 2, wherein R is hydrogen, —CN or —CF. 5. A compound according to claim 2, wherein R is —CN or —CF. 6. A compound according to claim 2, wherein R is hydrogen or (C-C) alkyl. A compound according to claim 2, wherein R is hydrogen, methyl or allyl. A compound according to claim 2, wherein R is methyl or allyl. The compound of claim 2,
