ANTHONY ESTRADA,ALAN OLIVERO,SNAHEL PATEL,MICHAEL SIU
申请号：
ARP140101782
公开号：
AR096151A1
申请日:
2014.04.30
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: compounds of formula (1) or salts thereof, where r u00b9, R u00b2 and r u00b3 are each independently h, F, CL, BR, I, or rent c u2081 u208b u2086 haloalquilo c u2081 u208b u2086； x u00b9 is n or C - r u2074,Where r u2074 is selected from the group consisting of F, CL, BR, I, - (l u00b9) u2080 u208b u2081 alkyl - (c u2081 u208b u2086, l u00b9) u2080 u208b u2081 - haloalquilo c u2081 u208b u2086, - (l u00b9) u2080 u208b u2081 - heteroalquilo c u2081 u208b u2086, - ( u2080 u208b u2081 - c u2083 u208b u2088 cycloalkyl, L u00b2)- (L u00b2) u2080 u208b u2081 - heterocicloalquilo 3 to 7 members, - (aryl u2080 u208b u2081 L u00b2) - 6 - 10 members - (heteroaryl u2080 u208b u2081 L u00b2) - 5 - 10 members, where l u00b9 is selected from the group consisting of - or - N (H) -, -, - S -,N - (alkyl = or c u2081 u208b u2086), and L u00b2 is selected from the group consisting of - or - N (H) - N - (alkyl c u2081 u208b u2086) -, - S -, = or, alquileno c u2081 u208b u2084, alquenileno c u2081 u208b u2084, alquinileno c u2081 u208b u2084, alcoxileno c u2081 u208b u2084,Aminoalquileno c u2081 u208b u2084, tioalquileno c u2081 u208b u2084 and heteroalquileno c u2081 u208b u2084,And in the r u2074 is optionally substituted carbon Atoms with rr u2074 heteroatoms and substituents selected from the group consisting of F, CL, BR, I, c u2081 u208b u2086 alkyl, haloalquilo c u2081 u208b u2086,Cycloalkyl 3 - 5 members, heterocicloalquilo 3 - 5 members, c u2081 u208b u2086 alkoxy, alquilamino c u2081 u208b u2086, dialquilamino c u2081 u208b u2086, Alquiltio c u2081 u208b u2086, =, or - nh u2082, CN- no u2082 and sf u2085； X is n or CH, is selected from the group consisting c u2081 u208b u2086 haloalquilo c u2081 u208b u2086 alkyl, cycloalkyl, dialquilamino c u2081 u208b u2086, 3 to 12 members, heterocicloalquilo 3 to 12 members,Where is optionally substituted with 1 - 5 ra substituents selected from the group consisting of F, CL, BR, I, - Oh, - CN, - - no u2082, sf u2085, alkyl
