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NEW TRICYCLIC COMPOUNDS
专利权人:
ЭББОТТ ЛЭБОРЕТРИЗ (US)
发明人:
ХОУМАНН Майкл З. (US),УИШАРТ Нейл (US),АРДЖИРИАДИ Мария А. (US),БРЕЙНЛИНДЖЕР Эрик К. (US),КОЛДЕРВУД Дэвид Дж. (US),ЭРИКССОН Анна М. (US),ФИАМЕНГО Брайан А. (US),ФРЭНК Кристин Е. (US),ФРИДМАН Майкл (US
申请号:
RU2012127368/04
公开号:
RU2012127368A
申请日:
2010.12.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. The compound of the formula its pharmaceutically acceptable salts, prodrugs, biologically active metabolites, stereoisomers and isomers, where R is H, deuterium, halogen, CF, CN, OR, N (R) (R), OCF, -C (O) -N ( R) (R), —C (O) —OR, —C (O) — optionally substituted (CC) alkyl, —C (O) — optionally substituted (CC) cycloalkyl, —C (O) — optionally substituted (CC ) aryl, —C (O) — optionally substituted (CC) heteroaryl, —C (O) — optionally substituted (CC) heterocyclyl, —S — optionally substituted (CC) alkyl, —S (O) — optionally substituted (CC) alkyl, —S (O) — optionally substituted (CC) alkyl, —S (O) N (R) (R), optionally optionally substituted (CC) alkyl, optionally substituted (CC) alkoxy, optionally substituted (CC) alkenyl, optionally substituted (CC) alkynyl, optionally substituted (CC) cycloalkyl, optionally substituted (CC) heteroaryl, optionally substituted (CC) heterocyclyl or optionally substituted (CC) aryl; or R is -Ζ-L-Ζ, where Z is optionally substituted (CC) alkylene, optionally substituted (CC) heteroarylene, optionally substituted (CC) heterocyclylene or optionally substituted (CC) arylene; L is a bond, optionally substituted (CC) alkylene, —CHC (O), —C (O) -, —C (O) CH—, —N (R) -, —O—, optionally substituted (CC) alkylene-N (R) C (O) -, optionally substituted (CC) alkylene-C (O) N (R) -, -C (O) N (R) -, -N (R) C (O) -, -C (O) N (R) - optionally substituted (CC) alkylene-, -N (R) C (O)-optionally substituted (CC) alkylene-, -C (O) N (R)-optionally substituted (CC) alkylene-C (O), -N (R ) C (O) optionally substituted (CC) alkylene-C (O) -, -C (O) optionally substituted (CC) alkylene-N (R) C (O) -, -C (O) optionally substituted (CC) alkylene-C (O) N (R) - optionally substituted (CC) alkylene-N (R) C (O) -, -N (R) C (O) optionally substituted (CC) alkylene, optional1. Соединение формулыего фармацевтически приемлемые соли, пролекарства, биологически активные метаболиты, стереоизомеры и изомеры, гдеRпредставляет собой Н, дейтерий, галоген, CF, CN, OR, N(R)
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