The piridona and aza piridona compounds (1) in the formula are provided,It includes three-dimensional isomers that can be used to inhibit Btk quinasa and treat immune disorders such as Btk quinasa, Tao Qiangji and its pharmaceutically acceptable salts. Methods for the use of formula compound (1) in vitro, in-situ and in-situ diagnostics, and how to treat disorders of mammalian cells or related pathological conditions are described. Claim 1: a compound (1) selected from the formula,Or its stereoisomer, tauqianglos or its pharmaceutically acceptable salts: R1 is h, D, F, Cl, cn-nh832222；-NHCH₃,-N (CH)-Oh, oc832323,-8 832283；-OCH₂CH₂OH, heteroaryl selected from imidazolyl and pyrazolyl, heterocyclyl selected from oxetanyl and azetidinyl and C₁₋₃ alkyl；R2,R3 and r830808 were selected independently from h, D, F, Cl, - nh832222；-NHCH₃,-N (CH)-Oh, oc832323,-8 832283；-OCH₂CH₂OH and C₁₋₃ alkyl；R8309ees arilo c8326c333183222； 8320 alternative substitution； carboccicio c83318321； - 8322222；C₂₋₂₀ heterocyclyl,C₁₋₂₀ heteroaryl,- (aril C) - (heterociclilo C)- (heteroaril C) - (heterociclilo C)- (C₁₋₂₀ heteroaryl) - (C₁₋₆ alkyl) or - (C₁₋₂₀ heteroaryl) -C (= O) - (C₂₋₂₀ heterocyclyl)；R es H F -NH-OH or optionally substituted C₁₋₃ alkyl； X is S, S (= O),S (3DO)N. No. 8310,Or cr831181；R831111 was independently selected from h, D, F, Cl, - ch832323；-CH₂CH₃,-CN, -CH₂F, -CHF₂,-CF8323,-NH832222,-OH and -OCH₃；Y1 e Y2 is a separate cr8310 and N； Z1,Uh...Z y Z est n seleccionados de modo independiente C CR y N Z est seleccionado de -C (R) --C (=O)-N (R) --C (R) C (R) --C (R) C (3DO) --CR3=CR3-.-CR3=N-,-N (R) C (R) --N (R⁶) C (R³) ₂C (R³) ₂- and -OC (R³) ₂C (R³) ₂-；One Z1 and Z2 or X and Z1,X is not s, s (= O) or s (= O) 832222,it forms an aryl, carbocyclyl, heterocyclyl or heteroaryl ring of five, six or seven members； where alkyl, carbocyclyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more groups independently selected from D, F, Cl, Br, I, -CH₃,-CH₂CH₃,-CH
