您的位置: 首页 > 农业专利 > 详情页

Process for preparing compounds of acid 4 - amino - 5 - Diphenyl - 4 - il - 2 - Hydroxymethyl - 2-methyl pentanoic acid
专利权人:
INC.;THERAVANCE
发明人:
MIROSLAV RAPTA
申请号:
ARP130100413
公开号:
AR089955A1
申请日:
2013.02.08
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
1. Characteristic requirement 1: preparation process of formula compound (1) or formula salt, wherein a is 0 or 1; r83088 is selected from halogen-ch8323a;-CF8323,Y-cn; B is an integer between 0 or 1 and 3; each r83099 is independently selected between halo-o-ch832323;-8.8323,and -CF₃;It is characterized in that the process includes resuspension of a compound in a formula (2) solvent to a formula (1) or a salt. 8. Claim 8: process for preparing a formula compound (3) or a formula salt, with the characteristic of a being 0 or 1; r83088 is selected from halogen-ch8323a;-CF8323,Y-cn; B is an integer between 0 or 1 and 3; each r83099 is independently selected between halo-o-ch832323;-8.8323,and -CF₃;The process includes the steps of (a) activating the carbohydrate group of a formula compound (1) and (b) reacting the product with a reducing agent to form a formula compound (3) or a salt. 11. Claim 12: a compound characterized by formula (4), wherein a is 0 or 1; r83088 is selected from halogen-ch83323;-CF8323,Y-cn; B is an integer between 0 or 1 and 3; each r83099 is independently selected between halo-o-ch832323;-8.8323,and -CF₃;T is H or P.There, P2 is an alcohol protection group, and u is h or P3,P3 is an ammonia protection group, or salt in it. Claim 17: a compound characterized by formula (5), wherein: R1 is selected from h-tar c832131;-No. c832183-83331-83231 - arilo c8326231-83218320;-[(D 8322) 8322;] [D 8321];-Lease of building c83218c83316c-oc (o) R1 83044;-alkylene C₁₋₆-NR¹¹R¹²,-C83218c83331-8326c (o) R1 m3;-C₀₋₆morpholinyl alkylene, -C₁₋₆-SO₂ alkylene-C₁₋₆ alkyl,Or other members of the formula group (6);R¹⁰ is selected from -alkyl C₁₋₆,-O-alkyl C₁₋₆,-O-cycloalkyl C₃₋₇,-CH CH (CH) -NHand -CH [CH (CH₃) ₂] -NHC (O) O-C₁₋₆-alkyl;R¹¹ and R¹² are -alkyl C₁₋₆ or are taken together as - (CH₂) ₃₋₆-,-C (O) - (CH) -o - (CH) O (CH) -R¹³ is selected from -O-C₁₋₆ alkyl,-O-benzyl, and -NR¹¹R¹²,A 0 or 1; r83088 was selected from halogen-ch-832303;-CF8323,Y-cn; B is an integer
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充