WOLFGANG SCHMIDT,CHRIS NIGHT,IAN LINNEY,LAURA CARZANIGA,ANDREA RIZZI,FABIO RANCATI
申请号：
ARP160100380
公开号：
AR103666A1
申请日:
2016.02.11
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Compounds that act as the opposite of muscle receptors, as enhancers for adrenaline B2 receptors, formulation processes, compounds containing these components, therapeutic uses, and combinations with other pharmaceutical active ingredients. 1. Characteristic requirement 1: a compound whose q is a set of formula (2) because it is a general formula (1)；Choose (3) or (4) from a combination of two different equations, 2 and 1,where A¹ and A² are independently absent or selected from C₁₋₁₂alkylene, C₃₋₈cycloalkylene and C₃₋₈heterocycloalkylene optionally substituted with one or more substituents selected from C₁₋₆alkyl, aryl-C₁₋₆alkyl and heteroaryl-C₁₋₆alkyl； B is absent or selected from C₃₋₈cycloalkylene, C₃₋₈heterocycloalkylene, arylene or heteroarylene optionally substituted with one or more groups selected from -OH, halogens, -CN, C₁₋₆alkyl, C₁₋₆alkoxy, C₁₋₆haloalkyl, C₁₋ ₆haloalkoxy and aryl-C₁₋₆alkyl； C is absent or is selected from -O-,-C (O) --OC (o)..- (O) CO-- yes.-S (O) --S (O) - y -N (R) -Or one of the c1-c23 remains of formula group (5),where R⁷ is independently H in each case or is selected from linear or branched C₁₋₈alkyl, aryl-C₁₋₆alkyl, arylsulfanyl, arylsulfinyl, arylsulfonyl, C₃₋₈cycloalkyl, C₃₋₈heterocycloalkyl, aryl, and heteroaryl； D is absent or is selected from C₁₋₁₂alkylene, C₂₋₁₂alkenylene, C₂₋₆alkylene, arylene, heteroarylene, C₃₋₈cycloalkylene, C₃₋₈heterocycloalkylene； wherein said arylene, heteroarylene, C₃₋₈cycloalkylene and C₃₋₈heterocycloalkylene is optionally substituted with one or more groups selected from -OH, halogen, -CN, C₁₋₆alkyl, C₁₋₆alkoxy,C₁₋₆haloalkyl, C₁₋₆haloalkoxy and aryl-C₁₋₆alkyl； n is in each case independently 0 or an integer between 1 and 3； m is in each case independently an integer between 1 and 3； E is absent or is selected from -O-,- No. 8311st --No. 8311-c (o)；-C (o) - No. 8311a；-OC (o)..-C (O) - (CH) -O--NR -C (O) - (CH) -O--8311-c (o) - 8311-y-s -；G is arileno or heterosexual, optionally replaced by one or mor
