ARAGON PHARMACEUTICALS INC.;SERAGON PHARMACEUTICALS INC.
发明人:
申请号：
IL22497613
公开号：
IL224976A
申请日:
2013.02.28
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
A compound that has the structure of Formula (XII): wherein, X 1 is CH, CR 3 or N； X 2 is N, CH, or CR 3 ； Z is -OH or -OR 10 ； R 2 is C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, C 1 -C 4 deuteroalkyl, C 3 -C 6 cycloalkyl, or -C 1 -C 4 alkylene-W； W is hydroxy, halogen, CN, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, and C 3 -C 6 cycloalkyl； each R 3 is independently halogen, C 1 -C 4 alkyl, or C 1 -C 4 fluoroalkyl； each R 4 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl； each R 5 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl； R 6 is H, C 1 -C 4 alkyl, or halogen； R 7 is H, C 1 -C 4 alkyl, or halogen； R 9 is H, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl； R 10 is C 1 -C 6 alkyl； m is 0, 1, or 2； n is 0, 1, 2, 3, or 4； and p is 0, 1, or 2； or a pharmaceutically acceptable or N-oxide thereof.
