STEVEN P. GOVEK,NICHOLAS D. SMITH,MEHMET KAHRAMAN,JOHNNY Y. NAGASAWA,ANDILIY G. LAI,JACKALINE D. JULIEN,MARK R. HERBERT,CELINE BONNEFOUS,KARENSA L. DOUGLAS
申请号：
PT14155086
公开号：
PT2735562E
申请日:
2011.09.15
申请国别(地区):
PT
年份:
2015
代理人:
摘要：
A compound that has the structure of Formula (XII): wherein, X 1 is CH, CR 3 or N X 2 is N, CH, or CR 3 Z is -OH or -OR 10 R 2 is C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, C 1 -C 4 deuteroalkyl, C 3 -C 6 cycloalkyl, or -C 1 -C 4 alkylene-W W is hydroxy, halogen, CN, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, and C 3 -C 6 cycloalkyl each R 3 is independently halogen, C 1 -C 4 alkyl, or C 1 -C 4 fluoroalkyl each R 4 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl each R 5 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl R 6 is H, C 1 -C 4 alkyl, or halogen R 7 is H, C 1 -C 4 alkyl, or halogen R 9 is H, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl R 10 is C 1 -C 6 alkyl m is 0, 1, or 2 n is 0, 1, 2, 3, or 4 and p is 0, 1, or 2 or a pharmaceutically acceptable or N-oxide thereof.
