ANTHONY ESTRADA,SNAHEL PATEL,JOSEPH P. LYSSIKATOS,MICHAEL SIU,GUIBAI LIANG,MALCOLM HUESTIS,WEN LIU,KEVIN CHEN
申请号：
ARP140104786
公开号：
AR098853A1
申请日:
2014.12.19
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
This also provides Methods of using compounds of formula (1) and compositions comprising compounds of formula (1) as inhibitors of DLK and Treat diseases and neurodegenerative disorders.Claim 1: a compound of formula (1), and salts thereof； in the formula (1) r u00b9a is selected from the group consisting of H, F, CL, heterocicloalquilo 3 to 12 members, heteroaryl 5 or 6 members, u2080 u208b u2081 - - (x u00b9a) or u00b9a u207b u00b9, - (x u00b9a) u2080 u208b u2081 - sr u00b9a u207b u00b9, - ( u2080 u208b u2081 x u00b9a) - S (o) r u00b9a u207b u00b9,- ( u2080 u208b u2081 x u00b9a) - S (o) and ( u2080 u208b u2081 u2082r u00b9a u207b u00b9 x u00b9a) - N - (r u00b9a u207b u00b9) u2082 x u00b9a； each is selected from the group consisting alquileno regardless c u2081 u208b u2084, haloalquileno c u2081 u208b u2084, heteroalquileno c u2081 u208b u2084, alquinileno c u2082 u208b u2084 and alquinileno c u2082 u208b u2084； r u00b9a u207b u00b9 whenever there is s Elecciona irrespective of the group consisting of hydrogen, alkyl c u2081 u208b u2086, haloalquilo c u2081 u208b u2086, heteroalquilo c u2081 u208b u2086, cycloalkyl 3-7 members,Cycloalkyl 3-7 members c u2081 u208b u2084 - alkyl -, heterocicloalquilo 3-7 members, heterocicloalquilo 3-7 members c u2081 u208b u2084 heteroaryl alkyl -, 5 - 6 members of 5 to 6 members, heteroaryl alkyl c u2081 u208b u2084 -, phenyl and phenyl alkyl c u2081 u208b u2084 -The United r u00b9a u207b u00b9 or any two groups at the same nitrogen Atom optionally combine to form a Heterocyclic Ring of 3 to 6 members comprising optionally 1 to 2 additional heteroatoms selected from N, o and SAnd in which a Group r u00b9a each time it appears is optionally substituted with 1 to 5 additional substituents selected from the group consisting r u00b9a u207b u00b2 regardless of F -, CL -, BR -, I -, - Oh, - CN, - no u2082, sf u2085 - alkoxy -, nh u2082, c u2081 u208b u2086, alquilamino c u2081 u208b u2086, dialquilam No c u2081 u208b u2086, alkyl c u
