1. A combination comprising (a) a phosphatidylinositol-3-kinase inhibitor selected from the group consisting of a compound of formula (I): wherein R is naphthyl or phenyl, wherein said phenyl is substituted with one or two substituents independently selected from the group consisting of halogen； lower alkyl unsubstituted or substituted by halogen, cyano, imidazolyl or triazolyl； cycloalkyl； an amino group substituted with one or two substituents independently selected from the group consisting of lower alkyl, lower alkylsulfonyl, lower alkoxyl group and (lower alkoxy) lower alkylamino group； piperazinyl unsubstituted or substituted by one or two substituents independently selected from the group consisting of lower alkyl and lower alkylsulfonyl； 2-oxopyrrolidinyl； (lower alkoxy) lower alkyl； imidazolyl； pyrazolyl； and triazolyl； R is O or S； R is lower alkyl； R is pyridyl unsubstituted or substituted with halogen, cyano, lower alkyl, lower alkoxy, or piperazinyl unsubstituted or substituted with lower alkyl； pyrimidinyl unsubstituted or substituted with a lower alkoxy group； quinolinyl unsubstituted or substituted with halogen； quinoxalinyl； or phenyl substituted by an alkoxyl group； R represents hydrogen or halogen； n represents 0 or 1； R represents an oxide group； provided that if n = 1, then the N-bearing radical R has a positive charge； R represents hydrogen or an amino group； or compounds of formula (II): where W is CR or N, where R is selected from the group consisting of: (1) hydrogen, (2) cyano, (3) halogen, (4) methyl, (5) trifluoromethyl, (6)1. Комбинация, содержащая (a) ингибитор фосфатидилинозитол-3-киназы, выбранный из группы, состоящей из соединения формулы (I):гдеRпредставляет собой нафтил или фенил, где указанный фенил является замещенным одним или двумя заместителями, независимо выбранными из группы, состоящей из галогена； низший алкил, незамещенный или замещенный галогеном, цианогруппой, имидазолилом или триазолилом； циклоалкил； аминогруппу, замеще
