The University Of Georgia Research Foundation; Inc
发明人:
DHAR, Shanta,PATHAK, Rakesh
申请号：
EP14869421
公开号：
EP3080137A4
申请日:
2014.12.12
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Pt(IV) prodrugs include one or more conjugated cyclooxygenase inhibitor. Reduction of Pt(IV) to Pt(II) can result cisplatin and a cyclooxygenase inhibitor. For proof of concept, a Pt(IV) prodrug that can produce cisplatin and aspirin, Platin-A, was synthesized. Platin-A exhibited excellent anticancer and anti-inflammatory properties, which were better than the combination of free formulation of cisplatin and aspirin.
