KIM, JI DUCK,金知德,YOON, HONG CHUL,尹洪哲,KIM, IN WOO,金仁宇,CHO, MIN JAE,赵玟在,趙玟在,LEE, IN YOUNG,李仁瑛,LEE, SANG HO,李相昊,PARK, EUN KYUNG,朴银敬,朴銀敬,LIM, KWON JO,林权助,林權助,NAM, SANG HYUN,南祥铉,南祥鉉
申请号：
TW100136386
公开号：
TWI515191B
申请日:
2011.10.07
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a pharmaceutical composition comprising the same, and the use thereof. The benzoxazine benzimidazole derivative can be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1, without hyperthermia:wherein, R1, R2, R3, R4 and R5 are as defined in the specification.本發明揭示苯并苯并咪唑衍生物，其以化學式1表示，且作為類香草素受體1(vanilloid receptor-1)的拮抗劑，含其之醫藥組成物及其用途。該苯并苯并咪唑衍生物可用於預防或治療與類香草素受體1的拮抗活性有關的疾病而不會升高體溫：其中，R1、R2、R3、R4及R5係如說明書所定義。
