KIM, JI DUCK,金知德,YOON, HONG CHUL,尹洪哲,CHO, SEONG HEE,赵成禧,趙成禧,KIM, INWOO,金仁宇,CHO, MIN JAE,赵玟在,趙玟在,LEE, IN YOUNG,李仁瑛,HYUN, HYAE JUNG,玄海钲,玄海鉦,PARK, EUNKYUNG,朴银敬,朴銀敬
申请号：
TW098112800
公开号：
TWI395747B
申请日:
2009.04.17
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention relates to a novel benzoxazine benzimidazole derivative of formula (1) as an antagonist against a vanilloid receptor-1, a pharmaceutical composition comprising the same as an active ingredient, and a use thereof. The benzoxazine benzimidazole derivative of the present invention may be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1:wherein, R1, R2, R3, R3’, Q1, Q2, Q3and Q4have same meanings as defined in the specification.本發明係關於一種作為對抗類香草精(vanilloid)受體-1之拮抗劑的式(1)之新穎苯并苯并咪唑衍生物、包含其作為活性成份的藥學組成物及其用途。本發明之苯并苯并咪唑衍生物可有用地用來防止或治療與類香草精受體-1的拮抗活性相關之疾病：其中R1、R2、R3、R3’、Q1、Q2、Q3及Q4具有與在專利說明書中所定義相同的意義。
