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Preparation of traditional Chinese medicine for diseases of cardio-cerebral blood vessels and their method of preparation
专利权人:
Tasly Pharmaceutical Group Co.; Ltd.
发明人:
CHENG, Yiyu,ZHANG, Haijiang,YE, Zhengliang
申请号:
ES05729109
公开号:
ES2635869T3
申请日:
2005.03.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Preparation of medication based on extracts obtained from Salviae miltiorrhizae root and Notoginseng root for use in the treatment of cardiovascular and cerebrovascular diseases, characterized in that the extracts comprise: ** Formula ** in which R1 is and R2 is, in the that the drug preparation has the physical and chemical parameters characterized as follows: in the HPLC spectrum, there are 8 peaks that have an individual peak area ratio with respect to total peak area greater than 2%; The average retention time of these 8 peaks is 6.04, 9.90, 16.89, 17.84, 20.31, 23.74, 27.73 and 31.02 respectively, the% of DER of the time The retention rate is 0.31, 0.25, 0.61, 0.70, 0.96, 0.76, 0.50 and 1.18 respectively; the average peak area is 1627.92, 2575.54, 366.89, 381.40, 186.08, 555.35, 281.91 and 1852.33 respectively, the% of DER of the peak area is 5.91, 13.53, 10.92, 13.81, 12.04, 10.48, 18.08 and 14.84, respectively; and the range of the ratio of individual peak area with respect to total peak area represents 19.6% -22.0%, 28.5-37.4%, 4.2% -5.2%, 4 , 2% - 5.5%, 2.1% -2.7%, 6.4% -7.8%, 3.0% -4.3% and 20.2% -27.2% respectively; wherein the above physical and chemical parameters are determined under the following conditions: (1) high performance liquid chromatography: charge: octadecylsilyl silica gel; flow rate: 1,000 ml / min; and detection wavelength: 280 nm; and (2) elution: mobile phase A: 0.02% aqueous phosphoric acid solution; mobile phase B: 0.02% aqueous phosphoric acid solution - 80% acetonitrile; and gradient elution: changing the mobile phase A from 90% to 78% homogeneously and changing the mobile phase B from 10% to 22% homogeneously for 0 to 8 min, the mobile phase A from 78% to 74% and mobile phase B from 22% to 26% for 8 to 15 min, and mobile phase A from 74% to 48% and mobile phase B from 26% to 52% during from 15 to 55 min; and in which the sample solution is prepared and determined through the following steps of: weighing tablets of the drug prepara
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