The present invention provides a system for guiding focused ultrasound energy release using a surgical navigation system and a method thereof, which are used to guide a focused energy onto a target point. The system comprises a focused ultrasound device, a surgical navigation system, and a holding fixture. The surgical navigation system may complete a calibration procedure according to the image of the portion to be processed on an object, the focus of the focused ultrasound device, and the tracking point provided by the surgical navigation system, and establish a positional relation between the focus and the image of the portion to be processed, such that the surgical navigation system may recognize the focus and guide the focused energy onto the target point.一種以手術導航系統導引聚焦式超音波釋放能量之系統及其方法,其係用於導引一聚焦能量於一目標點。該系統包括一聚焦式超音波裝置、一手術導航系統,以及一固定夾具,該手術導航系統根據一個體之待處理部位影像、聚焦式超音波裝置之聚焦點與手術導航系統提供之追蹤點完成校正程序,建立聚焦點與待處理部位影像之位置關係,使得手術導航系統得以辨識聚焦點並導引聚焦能量至目標點。