您的位置: 首页 > 农业专利 > 详情页

Selective and reversible inhibitors of the ubiquitin specific Protease 7, their pharmaceutical compositions and therapeutic applications
专利权人:
HYBRIGENICS S.A.
发明人:
FREDERIC COLLAN,MARIE-EDITH GOURDEL
申请号:
ARP120103228
公开号:
AR087757A1
申请日:
2012.08.31
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Drug composition and preparation process. Requirement 1: it consists of formula (1),Among them, R1,Each substance is the same o r different, selected from the halogen group, R, o r, NRR, CN, cf8323,C (O) R C (O) OR C (O) NRR NOC₁₋₆-OR alkylene, C₁₋₆-NRR alkylene, C₁₋₆-CO₂R alkylene, C₁₋₆-C (O) alkylene NRR, -O-C₁₋₆-CO₂R alkylene, -O-C₁₋₆-alkylene C (O) NRR, CO₂-alkylene C₁₋₆-OR, CO₂-alkylene C₁₋₆-NRR, C (O) NH-alkylene C₁₋₆-OR, C (O) NH-alkylene C₁₋₆-NRR, OCF₃,SO R SO H SO NRR NHSO R R C CR(R) (R) C 3DC (R)C₁₋₆-C (O) R alkylene, NHC (O) R, or C₁₋₆ alkyl,interrupted by at least one heteroatom, preferably chosen from O, N or S, preferably O; L¹ is linear or branched C₁₋₆ alkylene optionally substituted by one or more of = O, CN, C (O) R, C (O) OR or C (O) NRR, or CH₂-linear or branched C₁₋₆ alkylene , in which the subsequent C₁₋₆ alkylene is optionally substituted by one or more of halogen, OR, NRR or CF₃;Q is 0, 1, 2, 3 or 4; X is cr8311831;R⁷ is OR, halogen, linear or branched C₁₋₆-OR alkyl, C (O) OR, C (O) NRR, CN, OR⁹,NR SR; n is 0, 1 or 2; P is 1, 2 or 3; R 3,R830808,R831222 and r831222,each one is identical or different, they are chosen from the group consisting of H, linear or branched C₁₋₆-alkyl, halogen, OH, -O-Cilo-alkyl,NRR CN CFo. C (o) r, C (o) or C (o) NR; a was selected from the following groups:-C (O) NH--SO₂-;or -SO₂N-;L² is linear or branched C₁₋₆-O alkylene or linear or branched C₁₋₆ alkylene, optionally interrupted by at least one heteroatom chosen from O, NR or S and / or optionally substituted by: R, OR, NRR, alkyl C₁₋₆-OR C₁₋₆-NRR alkyl, OC (O) R, NHC (O) R, NHC (O) NRR, CN, C (= NH) NHOR; R⁶ is chosen from the group consisting of aryl, heteroaryl, cycloalkyl, heterocycle, H, in which the aryl, heteroaryl, cycloalkyl or heterocycle is mono or polycyclic and is optionally substituted by one or more linear or branched C₁₋₆ alkyl, halogen, NRR, CN, CF₃,OR, = O, C (O) R, C (O) OR, NHC (O) R, OC (O) R, linear or branched Cque alkenylene or CONRR; eac
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充