ХАДДАХ Мустафа (US),ТРАН Джо А. (US),ПЬЕР Фабрис (US),РИГАН Коллин Ф. (US),РАФФАЭЛ Николас Б. (US),РАВУЛА Сухитра (US),РАЙКМАН Дейвид М. (US)
申请号：
RU2012127792/04
公开号：
RU2012127792A
申请日:
2010.11.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound of formula (II) or (II ): OR BE pharmaceutically acceptable salt, solvate, and / or promedikament where: Z and Znezavisimo represent N or CR, or CH each independently selected from halo, -CN, -R , -OR, -S (O) R, -COOR, -CONR, and -NR, where each R is independently selected from H and optionally substituted C1-C4 alkyl, or wherein two R groups taken together with the nitrogen atom to which they are attached form an optionally substituted 5- or 6-membered heterocyclic ring which optionally contains in the ring one or more additional heteroatoms you Biranne from N, O and S each R, r and are independently selected from H and optionally substituted C1-C10 alkyl X is O, S, or NR Y is O or S, or NR wherein R c is selected from H, CN, optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, optionally substituted C2-C4 alkynyl, optionally substituted C1-C4 alkoxy and -NRR, Z is O or S L is a bond, -CR = CR-, -C≡ C-, -NR-, -O-, -S (O) -, - (CRR) -, - (CRR) -, -NR-, - (CRR) -O-, or - (CRR) -S ( O) - W represents an optionally substituted C1-C10 alkyl, optionally substituted C1-C10 heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, -NRR, -OR, -S (O) R, -CONRR, optionally substituted heterocyclyl, optionally substituted carbocyclyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, or -CRRR wherein each of R c and R are independently selected from H, optionally substituted C1-C10 alkyl, optionally substituted heteroalkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted carbocyclylalkyl, optionally substituted heterocyclylalkyl, optionally deputy
