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METHOD AND COMPOSITION
专利权人:
АПРЕА АБ (SE)
发明人:
БЮСТРЁМ Стюрбьёрн (SE),ЛИЛЙЕБРИС Шарлотта (SE),КАРАМ-ЛЕЛХАМ Нинус (SE)
申请号:
RU2012135698/15
公开号:
RU2012135698A
申请日:
2011.01.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A liquid composition which is an aqueous solution of a compound of formula (I) wherein R is selected from H, —CH — OR, —CH — S — R and —CH — NRR; R is selected from —CH-OR, —CH-S-R and —CH — NRR; R and R are the same or different independently selected from H; substituted or unsubstituted, unbranched or branched, saturated or unsaturated C3-C12 cycloalkyl or C1-C10 alkyl; substituted or unsubstituted benzyl; substituted or unsubstituted mono- or bicyclic aryl; substituted or unsubstituted mono-, bi- or tricyclic C2-C10 heteroaryl or non-aromatic C2-C10 heterocyclyl containing one or more heteroatoms independently selected from N, O and S; or R and Rb —CH — NRR are linked together and form, with the nitrogen atom to which they are attached, a substituted or unsubstituted non-aromatic C2-C10 mono- or bicyclic heterocyclyl, optionally containing one or more additional heteroatoms independently selected from N, O and S and optionally containing one or more cyclic keto groups; wherein the substituents of the substituted groups are independently selected from straight or branched, saturated or unsaturated C3-C12 cycloalkyl or C1-C10 alkyl; halogen; halogen-substituted C1-C10 alkyl, mono- or bicyclic aryl; mono-, bi- or tricyclic C2-C10 heteroaryl or non-aromatic C2-C10 heterocyclyl containing one or more heteroatoms independently selected from N, O and S; C1-C10 alkoxy groups; an amino group and a C1-C10 alkylamino group; and its pharmaceutically acceptable salts, a pH adjusting agent; wherein the aqueous solution has a pH value of from 3.0 to 5.0.2. The liquid composition according to claim 1, where R select1. Жидкая композиция, которая представляет собой водный раствор соединения формулы (I)в которой Rвыбирают из Н, -CH-O-R, -CH-S-Rи -CH-NRR;Rвыбирают из -CH-O-R, -CH-S-Rи -CH-NRR;Rи Rявляются одинаковыми или разными, независимо выбранными из Н; замещенного или незамещенного, неразветвленного или разветвленного, насыщенного или ненасыщенного С3-С12 циклоалкила или С1-
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