INDANONE DERIVATIVE, ITS PHARMACEUTALLY ACCEPTABLE SALT OR ENANTIOMER, METHOD FOR ITS PRODUCTION AND CONTAINING ITS PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF VIRAL DISEASE农业专利-农业学术服务平台

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INDANONE DERIVATIVE, ITS PHARMACEUTALLY ACCEPTABLE SALT OR ENANTIOMER, METHOD FOR ITS PRODUCTION AND CONTAINING ITS PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF VIRAL DISEASE

专利权人:: КОРЕЯ РИСЕРЧ ИНСТИТЬЮТ ОФ КЕМИКАЛ ТЕКНОЛОДЖИ (KR);КАТОЛИКЕ УНИВЕРСИТЕЙТ ЛЕВЕН К.У. ЛЕВЕН Р энд Д (BE)

发明人:: ДЗУНГ Янг Сик (KR),ЛИ Чонг Кго (KR),КИМ Хае Соо (KR),ДЗЕОНГ Хее Чун (KR),КИМ Пил Хо (KR),ХАН Соо Бонг (KR),СИН Дзин Соо (KR),НЭЙТС Йохан (BE),ТИБО Хендрик Ян (BE)

申请号：: RU2014101180/04

公开号：: RU2014101180A

申请日:: 2012.06.18

申请国别(地区):: RU

年份:: 2015

代理人:

摘要：: 1. The indanone derivative represented by the following chemical formula 1, a pharmaceutically acceptable salt thereof or an optical isomer thereof: [Chemical formula 1], wherein A, A, A and An are independently or optionally selected from the group consisting of —H, halogen, —OH, —CN , -N, C-Calkoxy, straight or branched C-C 1-6 alkyl, unsubstituted or substituted with -OH or methoxyphenylalkyl of 5-7 membered heterocycloalkyl, C-Caryl, -O (C = O) R, - (C = O) R, - (C = O) OR, -O (C = O) OR, -O (C = O) NRR, -NO, -NRR, -NR (C = O) R, -NR (C = S) R, -NR (C = O) OR, -NR (C = O) NRR, -NR (SO) R and -NR (C = S) NRR, or two or more adjacent substituents A, A, A and A together ring； D is —OH, halogen, straight or branched C — C alkyl, unsubstituted or substituted with phenyl C — C alkoxy, —O (CH) nOH, —O (C = O) R, - (C = O) R, - (C = O) OR, -O (C = O) OR, -O (C = O) NRR, -NO, -NRR, -NR (O) R, -NR (C = O) R, -NR (C = S) R, -NR (C = O) OR, -NR (C = O) NRR or -NR (C = S) NRR； E is halogen, -OH, -CN, -N = C = O , -N, C-alkoxy, -O (C = O) R, - (C = O) R, - (C = O) OR, -O (C = O) OR, -O (C = O) NRR , -NO, -NRR, -NR (C = O) R, -NR (C = S) R, -NR (C = O) OR, -NR (C = O) NRR, -NR (C = O) NROR, -NR (SO) R, -NR (C = S) NRR, -NR (P = O) (OR) or； G, G, G and G are independently or optionally selected from the group consisting of -H, halogen, - OH, CN, C 1 -C 4 alkoxy, straight or branched C 1 -C 1-6 alkyl, C 1 -Caryl, -O (C = O) R, - (C = O) R, - (C = O) OR, - (CH) - ( C = O) OR, -O (C = O) OR, -O (C = O) NRR, -NO, -NRR, -NR (C = O) R, - NR (C = S) R, -NR (C = O) OR, -NR (C = O) NRR and -NR (C = S) NRR, or two or more adjacent substituents G, G, G and G together can form a ring ； X represents hydrogen, oxygen, sulfur, hydroxy, linear or branched C-C1-6 alkyl, linear or branched C-C1-6 alkylene, = N-NRR, -NR-OR or = N-OR； Y represents -O-, -CH- , -NH- or - (NR) -； R is - (C = O) H, - (C = O) OH, - (C = O) R, - (C = S) R or - (C = O) OR； Z is C or N； R, R, R, and R are independently hy