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СОДЕРЖАЩИЕ ФОСФОР СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
专利权人:
ЦЗЯНСУ ХЭНСОХ ФАРМАСЬЮТИКАЛ КО.; ЛТД. (CN)
发明人:
ХУ Байхуа (US),ХЭ Кань (US),ЧЖАН Миньшэн (US)
申请号:
RU2013141274/04
公开号:
RU2013141274A
申请日:
2012.02.22
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A compound of formula (I) or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein Y represents N or CR Lnezavisimo L and are selected from the group consisting of a bond, -O-, -N (H) -, -S-, -OR-, -SR-, -NR-, -RNR-, -ROR- -C (O) N (R) -, -NRC (O) -, -C (O) NR-, -RS (O) -, -RS (O) R-, -RS (O) NR-, -NRS (O) R-, -C (O) R-, -OC (O) NR-, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted C-aryl, unsubstituted or substituted C-carbocycle, unsubstituted or substituted 3-12 membered heterocycle and an unsubstituted or substituted 3-12 membered th heteroaryl wherein L and Lmogut attached to any position of the group and where r is an integer from 0 to 2 Wvybran from the group consisting of unsubstituted or substituted C-carbocycle, unsubstituted or substituted 3-12 membered heterocycle, unsubstituted or substituted C-aryl, unsubstituted or substituted heteroaryl, in the case when C-aryl or heteroaryl substituted with only two substituents, the two substituents are not in the para position Wvybran from the group consisting of unsubstituted or C-substituted aryl, and substituted or unsubstituted 3-12 membered heteroaryl R c is selected from the group consisting of water genus, halogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, -SR, -S (O) R, -S (O) R, -S (O) NRR, -NO, -NRR, - CN, -C (O) R, -OC (O) R, -OR, -CONRR, -NRC (O) R, substituted or unsubstituted C-cycloalkyl, unsubstituted or substituted C-aryl, unsubstituted or substituted 3-12- membered heterocycle and an unsubstituted or substituted 5-12 membered heteroaryl r and are independently selected from the group consisting of hydrogen, halogen, unsubstituted or substituted
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