ЛАМПЕ Джон В. (US),ВАТСОН Пол С. (US),ВИТТИТОУ Джейсон Л. (US),ПИТЕРСОН Уорд М. (US)
申请号：
RU2013107007/04
公开号：
RU2013107007A
申请日:
2011.07.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound of Formula III or a corresponding pharmaceutically acceptable salt or solvate thereof, Formula IIIQ is C = O, SOili (CRR) nravno 1, 2 or 3 nravno 1 or 2 nravno 0, 1, 2 or 3, wherein the ring predstavlennyyneobyazatelno substituted alkyl, halo, oxo, oR, NRRili SR Rvybirayut of the following heteroaryl systems, optionally substituted: R-independently mean H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl or tsikloalkilalkinil optionally substituted Ar is a monocyclic aryl , bicyclic aryl, monocyclic rd heteroaryl or bicyclic heteroaryl Hee Xlibo absent or represent substituents on Ar and independently in the form Y-Z and YZ, where Z and Zprisoedineny to Ar Yoznachaet O, CO, NR, SONR, NRSO, NRCO or N-containing heteroaryl Y and Ynezavisimo selected from the group consisting of: H, halogen, OR, NRR, NO, SR, SOR, SOR, SONRR, NRSOR, OCF, COR, CONRR, NRC (= O) R, NRC (= O) OR, OC ( = O) NRR, NRC (= O) NRR, N-containing heterocyclic or N-containing heteroaryl Z, Z and Znezavisimo selected from the group consisting of: alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, loop alkyl alkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, heterocycle, (heterocycle) alkyl, (heterocycle) alkenyl, (heterocycle) alkynyl, and absent R-independently selected from the group consisting of: absent, H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylalkenyl, tsikloalkilalkinil, heterocycle, heteroaryl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, (heterocycle) alkyl, (heterocycle) alkenyl, (heterocycle) alkynyl, or heterocycle neobyaz1. Соединение формулы III или соответствующая фармацевтически приемлемая соль или сольват,Формула IIIQ означает C=O, SO2 или (CR4R5)n3n1 равно 1, 2 или 3n2 равно 1 или 2n3 равно 0, 1, 2 или 3где цикл, представленныйнеобязательно
