DERIVADOS DE N-(HETERO)ARIL-PIRROLIDINA DE PIRAZOL-4-IL-PIRROLO[2,3-D]PIRIMIDINAS Y PIRROL-3-IL-PIRROLO[2,3-D]PIRIMIDINAS COMO INHIBIDORES DE LA QUINASA JANUS
RODGERS, JAMES D.,SHEPARD, STACEY,ARVANITIS, ARGYRIOS G.,WANG, HAISHENG,STORACE, LOUIS,FOLMER, BEVERLY,SHAO, LIXIN,ZHU, WENYU,GLENN, JOSEPH
申请号：
PE0019952011
公开号：
PE09102012A1
申请日:
2010.05.21
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula (i) wherein: X is halogeno, cyano, and CH, N Z is H, c1-c4 alkyl, c1-c4 alkyl fluoride, F, ar is phenyl heteroaryl heteroaryl bicyclic monociclico C1 - C6 C1 - C7 C9 -- C14, cicloalquilarilo, among others.Preferred compounds are: 3 - [1 - (6 - cloropirazin - 2 - il) pyrrolidin-3-yl] - 3 - [4 - (7H pyrrolo [2,3-d] pyrimidin-4-yl) - 1H pyrazol-1-yl] propanenitrile 3 - [1 - (1 - Oxide - 2.3 - dihidrotieno [2,3-b] pyridin-3 (IL - 6) - pyrrolidin-3-yl] - 3 - [3 - (7H pyrrolo [2,3-d] pyrimidin-4-yl) - 1H pyrrole - triazin-1-yl] propanenitrile 2 - (3 - (2 - cyano - 1 - [4 - (7 H pyrrolo [2,3 - d] pyrimidin-4-yl) - 1H pyrazol-1-yl] ethyl} pyrrolidin-1-yl) - 6 - (methylthio) benzonitrile among others. These compounds are jak inhibitors useful in the treatment of inflammatory disorders, autoimmune Disorders and cancerSE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: X ES CIANO, HALOGENO Y ES CH, N Z ES H, ALQUILO C1-C4, ALQUILO FLUORADO C1-C4, F AR ES FENILO, HETEROARILO MONOCICLICO C1-C6, HETEROARILO BICICLICO C1-C9, CICLOALQUILARILO C7-C14, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-[1-(6-CLOROPIRAZIN-2-IL)PIRROLIDIN-3-IL]-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]PROPANONITRILO 3-[1-(1-OXIDO-2,3-DIHIDROTIENO[2,3-b]PIRIDIN-6-IL)PIRROLIDIN-3-IL]-3-[3-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRROL-1-IL]PROPANONITRILO 2-(3-{2-CIANO-1-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]ETIL}PIRROLIDIN-1-IL)-6-(METILTIO)BENZONITRILO ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES JAK UTILES EN EL TRATAMIENTO DE TRANSTORNOS INFLAMATORIOS, AUTOINMUNES Y CANCER
