The invention relates to a formula pyridine derivative (I),If you are already registered, please log in first.(b) and (c);R1 is h, C1-C4 tar, halide, ammonia water, etc.; R3 is h, C1-C4 tar, halide, Alcoy C1-C4; R4 is phenyl, tienilo, pirid Nile, tiazolilo, etc.; R5 is h, C1-C4 tar, halogen, etc.; R6 is h, or C1-C4 tar; R7 is e-w-y; W is a single ring or bicycle heterosexual with 5 or 6 members, including a nitrate atom, alternative 1, 2 or 3 other heterosexual atoms, such as O, s and N, which can be replaced by R8; R8 is h, C1-C4, cyclo-c7, etc.; and A. single or heterocyclic arilo consisting of 5 or 6 members, including 1 nitro absorbent, and alternative 1, 2 or 3 heteromorphs, such as O, N and s, may be replaced by R9 and r9a;R9 is the tar of C1-C4, alcoxi C1-C4, halogen, etc.; r9a is the tar of C1-C4 or halogen; N and m are 1 or 2. , 1,1,1,1,1,1] [1,1,1,1,1,1,1,1. A drug synthesis and preparation procedure was also mentioned. These compounds are inhibitors of Akt proteins and can be used in cancer treatment.REFERIDA A UN DERIVADO DE PIRIMIDINA DE FORMULA (I), DONDE EL ANILLO B SE SELECCIONA DE (a), (b) Y (c); R1 ES H, ALQUILO C1-C4, HALOGENO, AMINO, ENTRE OTROS; R3 ES H, ALQUILO C1-C4, HALOGENO, ALCOXI C1-C4; R4 ES FENILO, TIENILO, PIRIDINILO, TIAZOLILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C4, HALOGENO, ENTRE OTROS; R6 ES H O ALQUILO C1-C4; R7 ES -W-Y; W ES UN HETEROARILENO MONOCICLICO O BICICLICO DE 5 O 6 MIEMBROS QUE COMPRENDE UN ATOMO DE NITROGENO Y OPCIONALMENTE 1, 2 O 3 HETEROATOMOS ADICIONALES TALES COMO O, S Y N, OPCIONALMENTE SUSTITUIDOS CON R8; R8 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C7, ENTRE OTROS; Y ES H, ARILO O HETEROARILO MONOCICLICO DE 5 O 6 MIEMBROS QUE COMPRENDE 1 ATOMO DE NITROGENO Y OPCIONALMENTE 1, 2 O 3 HETEROATOMOS TALES COMO O, N Y S, OPCIONALMENTE SUSTITUIDOS CON R9 Y R9A; R9 ES ALQUILO C1-C4, ALCOXI C1-C4, HALOGENO, ENTRE OTROS; R9A ES ALQUILO C1-C4 O HALOGENO; n Y m SON 1 O 2. SON COMPUESTOS PREFERIDOS: 6-FENIL-7-(4-{[3-(5-PIRIDIN-2-IL-1,