BRANDL, TRIXI,RAMAN, PRAKASH,RIGOLLIER, PASCAL,SEEPERSAUD, MOHINDRA,SIMIC, OLIVER
申请号：
PE2011001774
公开号：
PE20120557A1
申请日:
2010.04.09
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It's an abiotic formula compound,WHERE R IS C1-C6 ALKYL, C2-C6 ALKYNYL OR C3-C7-ALKYL-C7-C4-ALKYL； R 'ES H, C1-C6 ALKYL, AMONG OTHERS； R1 AND R2 ARE H, C1-C6 ALKYL, C1-C6 ALKOXYL, AMONG OTHERS； R4 IS C1-C8 ALKYL, C3-C8 CYCLLOALKYL, AMONG OTHERS； J IS A DIVALENT LINK OR RESIDUE OF FORMULA -NR6-CH (R5) -C (= O) -；R5 is the tar of C1-C8, cycloquilo c3-c8, etc.； R6 is the tar of H or C1-C4； G is a formula group e-r7； E is a link, CH2, C (o),S (O) 2, AMONG OTHERS； R7 IS C1-C6 ALKYL, C1-C6 HALOALKYL, C1-C6 ALCOXYL, AMONG OTHERS. THEY ARE PREFERRED COMPOUNDS: (5R, 8S) -7 - [(2S) -2 - {[(2S) -2-CICLOHEXIL-2 - ({[(2R) -1-ETIL-PIRROLIDIN-2-IL] -CARBONYL } -AMINO) -ACETIL] -AMINO} -3,3-DIMETIL-BUTANOIL] -10,10-DIMETIL-N - {(1R, 2S) -1 - [(PIRROLIDIN-1-IL-SULFONIL) -CARBAMOIL] -2-VINIL-CICLOPROPIL} -7-AZA-DI-ESPIRO- [3.0.4.1] -DECAN-8-CARBOXAMIDE, (5R, 8S) -7 - [(2S) -2 - {[(2S) -2 - {[(1-TERBUTYL-AZETIDIN-2-IL) -CARBONYL] -AMINO} -2-CYCLOHEXIL-ACETIL] -AMINO} -3,3-DIMETIL-BUTANOIL] -10,10-DIMETIL-N - {( 1R, 2S) -1 - [(PIRROLIDIN-1-IL-SULFONIL) -CARBAMOIL] -2-VINIL-CICLOPROPIL} -7-AZA-DI-ESPIRO- [3.0.4.1] -DECAN-8-CARBOXAMIDE,There are others These compounds are NS3-4A protein inhibitors of hepatitis C virus.REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE R ES ALQUILO C1-C6, ALQUENILO C2-C6 O CICLOALQUILO C3-C7-ALQUILO C0-C4； R' ES H, ALQUILO C1-C6, ENTRE OTROS； R1 Y R2 SON H, ALQUILO C1-C6, ALCOXILO C1-C6, ENTRE OTROS； R4 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, ENTRE OTROS； J ES UN ENLACE O UN RESIDUO DIVALENTE DE FORMULA -NR6-CH(R5)-C(=O)-； R5 ES ALQUILO C1-C8, CICLOALQUILO C3-C8, ENTRE OTROS； R6 ES H O ALQUILO C1-C4； G ES UN GRUPO DE FORMULA -E-R7； E ES UN ENLACE, CH2, C(O), S(O)2, ENTRE OTROS； R7 ES ALQUILO C1-C6, HALOALQUILO C1-C6, ALCOXILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (5R,8S)-7-[(2S)-2-{[(2S)-2-CICLOHEXIL-2-({[(2R)-1-ETIL-PIRROLIDIN-2-IL]-CARBONIL}-AMINO)-ACETIL]-AMINO}-3,3-DIMETIL-BUTANOIL]-10,10-DIMETIL-N-{(1R,2S)-1-[(PIRROLIDIN-1-IL-SULFONIL
